Zofran is a medication that contains the active ingredient ondansetron hydrochloride. Zofran is used for preventing nausea and vomiting in certain instances, including postoperatively and during some instances of chemotherapy and radiotherapy in cancer patients. Zofran belongs to a class of medications known as 5-HT 3 receptor antagonists. Found centrally and peripherally in the nervous system, these receptors may be affected by Zofran in both areas and produce a relief from symptoms of emesis.
Zofran is not thought to antagonize dopamine receptors. After oral administration, the active ingredients in Zofran generally demonstrate a half-life of under 7 hours. The majority of Zofran's active ingredients are bound to proteins in the plasma and the drug is largely eliminated as conjugated metabolites in the urine. Generic Zofran is affordable, costing roughly 90 cents per Zofran 4 mg ODT for people paying out of pocket. Insurance may also help cover the costs associated with a Zofran prescription and Zofran coupons are also available through the manufacturer or online at times.
It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Do not let anyone else take your medication.
Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ondansetron pronounced as on dan' se tron. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow?
What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names. I was sick for days but never fainted. My Dad's first symptom was when he passed out, but by the next day he was back to normal. In the medical world, Zofran is used extremely commonly, particularly in the emergency department. It is really no longer just for chemo-induced nausea - it is regularly used for simple gastroenteritis and I often see it used as first line by obstetricians for nausea of pregnancy, even though vitamin B6 and doxylamine an over the counter antihistamine are cheaper recommended first line agents.
It is absolutely one of my top 5 most prescribed medications. Phenergan, Compazine, and Reglan are also great anti-nausea drugs, but they also have some pretty unfortunate side effects for some people. On the other hand, I've given literally thousands of doses of Zofran and I've never seen a single side effect from it.
It's true that prolonged QT can cause a fatal arrhythmia, but I actually agree with you - plenty of things sold over the counter can kill you. Zofran is just as safe as many if not most over the counter medications.
It should be over the counter. I wouldn't be surprised if it is available over the counter within the next 10 years. I'd lose a lot of business but I wouldn't mind! Hmmm, we'll see who is right. Because I kind of expect it to be even more restricted as I said. It is possible we could both be right. Still, Zofran is such a popular medication, and it has far more utility than the coxibs.
I should note that I just realized that the comment linked in the question was my own, so I just repeated myself to some extent - obviously this is just my opinion as one doctor who sees a lot of people for whom Zofran is a useful treatment.
But based on patterns I've seen in the past 5 years, I definitely feel it's being prescribed more freely as physicians who trained since it went generic go into practice, and I believe that trend will continue even if a boxed warning came out for it. But there is a not insignificant subsegment of the population who would be at risk with a much smaller dose, namely, people with congenital QT prolongation not all of whom are aware they have this problem and people on other medications that prolong the QT, such as methadone, hydrochlorothiazide, and furosemide - all very common prescription meds, and as you saw, there are many more examples.
This is part of the reason why prescription meds that combine Tylenol with other pain medications recently got a black box warning. People take multiple Tylenol-containing medications without realizing it too frequently, and the resulting liver failure can be fatal. The FDA has to take into account the fact that we have an aging and diverse populace who would be accessing these meds if they were over the counter, we can't expect most people to know whether their combination of medications would be likely to produce a dangerous QT change.
Dystonic reactions are rare, but can occur with a regular dose of Zofran or other prescription anti-emetics and certain other classes of prescription medications. Generic Zofran is still incredibly expensive. Actually, the last time I checked, which was admittedly a couple of years ago, a month's supply of generic Zofran for 8 mg tabs was more than a thousand dollars! Prescription plans can be a bit of a racket, where the consumer is only concerned with the co-pay, but the plan pays the deep costs.
Prescription plans buffer the cost with co-pay maximums, so people really are not aware of how much the insurer is actually paying. I'm guessing that as a geneirc consumers would howl at the charges, there would be no insurance buffer and people would not buy it. The return for pharma is more reliable through prescription reimbursement. Would you spend 50 bucks for a single pill?
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